Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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7,351 – 7,365 of 178,220 results

7,351

eMolecules 2383003-60-7 | OF-C4-Deg-Lin | Medchem Express1594.526 | C100H176N4O10 | 98.000 | CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCCCCN(CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)CCCC[C@@H]1NC(=O)[C@H](CCCCN(CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)NC1=O | 5mg | 808298203

OF-C4-Deg-Lin | Medchem Express | 2383003-60-71594.526 | C100H176N4O10 | 98.000 | CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCCCCN(CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)CCCC[C@@H]1NC(=O)[C@H](CCCCN(CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)CCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC)NC1=O | 5mg | 808298203

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7,352

Medchemexpress LLC Gsk3145095 | 1622849-43-7 | 99.4% | 397.38 | 25 MG

GSK3145095 is a potent RIP1 kinase inhibitor with an IC50 of 6.3 nM. This compound is intended for research applications only and is not suitable for patient use.

Functions as a RIP1 kinase inhibitor
Exhibits an IC50 of 6.3 nM
Suitable for research use

Pricing & Availability

7,353

Medchemexpress LLC NSC 107512 | 22242-89-3 | 99.97% | C12H16N6O5 | 1 ML

NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). It belongs to a class of sangivamycin-like molecules (SLM). It inhibits growth and induces apoptosis of multiple myeloma tumors.

Potent inhibitor of cyclin-dependent kinase 9 (CDK9)
Belongs to a class of sangivamycin-like molecules (SLM)
Inhibits growth of multiple myeloma tumors
Induces apoptosis of multiple myeloma tumors

Pricing & Availability

7,354

Medchemexpress LLC LSN3318839 | 2764704-18-7 | 99.22% | C26H23Cl2N3O2 | 1 ML

LSN3318839 is an orally active positive modulator of the glucagon-like peptide-1 receptor (GLP-1R). It increases the secretion of insulin and has a blood sugar-lowering effect. For research use only.

Enhances potency and efficacy of GLP-1(9-36) in GLP-1R-expressed HEK293 cells
Increases insulin secretion in INS-1 832-3 cells with high glucose presence
Demonstrates hypoglycemic effect in hyperglycemic mouse models
Offers an improved effect when co-administered with Sitagliptin

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7,355

Apexbio Technology LLC type II collagen fragment 25mg

Type II collagen fragment is a degradation product of type II collagen the principal fibrillar collagen in cartilage extracellular matrix It is not a small-molecule inhibitor or agonist but a biomarker reflecting cartilage metabolism and matrix remodeling The generation of type II collagen fragments is associated with enzymatic degradation of cartilage particularly in pathological conditions like osteoarthritis These fragments do not have a direct mechanism of action or activity profile but serve as valuable tools for studying cartilage turnover and joint diseases Based on these properties type II collagen fragments hold research potential in biomedical studies investigating cartilage metabolism matrix remodeling and the pathogenesis of joint diseases

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7,356

BIOHIPPO GATA3-TAG-BSD LV

GATA3-TAG-BSD is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a blasticidin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures

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7,357

Medchemexpress LLC WBC100 | 2095780-08-6 | 95.0% | C25H33NO7 | 1 ML

WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. It targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway and is utilized in research for c-Myc overexpressing tumors. This compound exhibits significant biological activity both in vitro and in vivo.

Acts as a potent, selective, and orally active c-Myc molecule glue degrader.
Targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway.
Selectively kills c-Myc overexpressing cancer cells with nanomolar IC50 values.
Shows higher IC50 values for c-Myc-low normal human cell lines.
Decreases c-Myc protein levels in cancer cells in a dose-dependent manner.
Exhibits dose-dependent antitumor activity in vivo.
Can eradicate MOLM-13-luciferase cells in vivo at effective doses.
Significantly inhibits tumor growth and prolongs survival in leukemia models.

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7,358

Medchemexpress LLC Exarafenib | 2639957-39-2 | 99.7% | 521.58 | 1 ML

Exarafenib is an orally-available, selective pan-RAF inhibitor that is effective in RAF-dependent cancers, including all classes of BRAF alterations. It suppresses MAPK signaling in RAF-dependent melanoma cell lines and demonstrates anticancer activity.

Orally-available, selective pan-RAF inhibitor
Effective against RAF-dependent cancers, including BRAF alterations
Suppresses MAPK signaling in RAF-dependent melanoma cell lines
Demonstrates anticancer activity

Pricing & Availability

7,359

Medchemexpress LLC Lazabemide (Ro 19-6327) | 103878-84-8 | 99.95% | C8H10ClN3O | 100 MG

Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B). It shows less activity for MAO-A and can inhibit monoamine uptake at higher concentrations. This compound is suitable for research concerning Parkinson's and Alzheimer's disease.

Selective, reversible inhibitor of MAO-B
Less active for MAO-A
Inhibits monoamine uptake at high concentrations
Useful in Parkinson's disease research
Useful in Alzheimer's disease research

Pricing & Availability

7,360

Medchemexpress LLC Cinobufotalin | 1108-68-5 | 458.54 | 1 MG

Cinobufotalin is a cardiotonic steroid or bufadienolide extracted from the skin secretions of giant toads. It has been used as a cardiotonic, diuretic, and hemostatic agent, and is also a potential anti-lung cancer agent. It is for research use only.

Cardiotonic steroid
Bufadienolide
Extracted from giant toad skin secretions
Functions as a cardiotonic, diuretic, and hemostatic agent
Potential anti-lung cancer properties
For research use only
Provided as 1 mg

Pricing & Availability

7,361

Medchemexpress LLC Skepinone-L | 1221485-83-1 | MFCD22572738 | C24H21F2NO4 | 1 MG

Skepinone-L is a chemical probe and a selective p38 mitogen-activated protein kinase inhibitor. It is the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity, making it a valuable probe for chemical biology research and potentially fostering the development of a unique class of kinase inhibitors.

Selective p38 mitogen-activated protein kinase inhibitor
First ATP-competitive p38 MAPK inhibitor
Excellent in vivo efficacy and selectivity
Valuable probe for chemical biology research
Potentially fosters the development of a unique class of kinase inhibitors

Pricing & Availability

7,362

Medchemexpress LLC VL285 | 1448188-57-5 | 99.3% | 532.65 | 1 ML

VL285 is a potent VHL ligand with an IC50 of 0.34 μM.

Potent VHL ligand.
Attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7.
Useful in cancer research.
Applicable in cancer targeted therapy.
Used as a ligand for E3 ligase.

Pricing & Availability

7,363

Apexbio Technology LLC Abametapir 1762-34-1 500mg

Abametapir (CAS 1762-34-1) is a small-molecule inhibitor targeting metalloproteinases It is designed to inhibit metalloproteinase enzymes involved in the egg hatching and survival processes of lice Abametapir exerts its biological activity primarily through inhibition of metalloproteinases In in vitro assays abametapir demonstrates ovicidal activity with reported IC50 values approximately in the low micromolar range Based on these pharmacological properties abametapir holds research potential in the management of head lice infestations and laboratory studies on ectoparasite enzyme inhibition and resistance development

Pricing & Availability

7,364

Medchemexpress LLC Carbamic acid, N-[(2S,3R)-2-methyl-4-oxo-3-oxetanyl]-, [1,1'-biphenyl]-4-ylmethyl ester | 1439366-66-1 | 99.7% | 311.33 | 25 MG

NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC50 of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-1 has the potential for the research of inflammation and pain.

Inhibitor type: potent and selective inhibitor of NAAA.
IC50: 7 nM.
Target: NAAA (N-acylethanolamine acid amidase), a cysteine amidase.
Function of NAAA: preferentially hydrolyzes endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA).
Research potential: potential for the research of inflammation and pain.

Pricing & Availability

7,365

Medchemexpress LLC GLP-1R agonist 4 | 2401894-26-4 | 98.26% | C32H30ClF2N3O5 | 50 MG

GLP-1R agonist 4 is a potent agonist of GLP-1R, an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. This compound has potential for research related to diabetes, as extracted from patent WO2019239319A1, compound 96. It is intended for research use only.

Potent agonist of GLP-1R
Potential for diabetes research
Available in various quantities
Appearance: Solid, white to off-white
Storage: Powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 6 months or -20°C for 1 month
Soluble in DMSO (100 mg/mL)
Protocols available for in vivo dissolution using various co-solvents

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Pyridines and derivatives

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Medchemexpress LLC Gsk3145095 | 1622849-43-7 | 99.4% | 397.38 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NSC 107512 | 22242-89-3 | 99.97% | C12H16N6O5 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LSN3318839 | 2764704-18-7 | 99.22% | C26H23Cl2N3O2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC type II collagen fragment 25mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO GATA3-TAG-BSD LV Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC WBC100 | 2095780-08-6 | 95.0% | C25H33NO7 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Exarafenib | 2639957-39-2 | 99.7% | 521.58 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lazabemide (Ro 19-6327) | 103878-84-8 | 99.95% | C8H10ClN3O | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cinobufotalin | 1108-68-5 | 458.54 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Skepinone-L | 1221485-83-1 | MFCD22572738 | C24H21F2NO4 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC VL285 | 1448188-57-5 | 99.3% | 532.65 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Abametapir 1762-34-1 500mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Carbamic acid, N-[(2S,3R)-2-methyl-4-oxo-3-oxetanyl]-, [1,1'-biphenyl]-4-ylmethyl ester | 1439366-66-1 | 99.7% | 311.33 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GLP-1R agonist 4 | 2401894-26-4 | 98.26% | C32H30ClF2N3O5 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More